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doi: 10.1152/physrev.00039.2013 166 ZhangYRomeroHSalinasGGladyshevVN

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It is conceivable that there is a high possibility of acquired resistance after treatment with KRAS (G12C) inhibitors 228

Loss-of-function mutations in lysosomal proteins, as seen in Niemann-Pick disease type C1 and Gaucher disease, disrupt lipid and cholesterol metabolism and result in profound neurodegeneration

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